In canine distemper, which finding is a negative prognostic indicator?

• A. Neurological signs present
• B. Absence of fever
• C. Normal appetite
• D. Early vaccination

Answer: (A)

Neurological involvement signals a poor prognosis because central nervous system invasion by the distemper virus indicates advanced disease with potential irreversible brain damage. Signs such as seizures, ataxia, and myoclonus reflect CNS injury and are associated with higher mortality and lasting deficits, making outcomes more guarded even with supportive care. Fever and appetite can be variable and are not as strongly predictive of outcome, while vaccination status matters before infection—early vaccination prevents disease, so it’s linked to a better prognosis overall, not a prognostic indicator once disease has started.