Parvo PCR is most sensitive at what time post-infection?

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Study for the Clinical Approach to Common Infections Test. Prepare using flashcards and multiple-choice questions, all with hints and explanations. Ace your exam!

Multiple Choice

Parvo PCR is most sensitive at what time post-infection?

Explanation:
PCR sensitivity hinges on how much viral DNA is present in the sample. After parvovirus infection, the virus replicates in rapidly dividing cells and shedding in feces increases, typically starting a few days after infection and peaking around day 7–10. At this peak, the viral load is highest, making the test most likely to detect the virus. Testing too early (when viral levels are still low) or later (as shedding wanes) reduces the chance of a positive result. So, around 10 days post-infection is when Parvo PCR is most likely to be positive.

PCR sensitivity hinges on how much viral DNA is present in the sample. After parvovirus infection, the virus replicates in rapidly dividing cells and shedding in feces increases, typically starting a few days after infection and peaking around day 7–10. At this peak, the viral load is highest, making the test most likely to detect the virus. Testing too early (when viral levels are still low) or later (as shedding wanes) reduces the chance of a positive result. So, around 10 days post-infection is when Parvo PCR is most likely to be positive.

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