Which antibiotic is included in the initial treatment plan for a cat bite abscess?

• A. Clavamox
• B. Doxycycline
• C. Clindamycin
• D. Azithromycin

Answer: (A)

Cat bite infections are typically polymicrobial, with Pasteurella multocida from the cat’s mouth and anaerobic bacteria driving the infection. An antibiotic chosen for initial treatment should cover both Pasteurella and anaerobes and be well absorbed to reach infected tissues. Amoxicillin-clavulanate (Clavamox) provides broad coverage against Pasteurella and anaerobes due to the clavulanate component inhibiting beta-lactamases, and it has good tissue penetration, making it the best first-choice therapy for a cat bite abscess. Doxycycline can cover Pasteurella but isn’t reliable for anaerobes. Clindamycin covers anaerobes but misses Pasteurella, a key bite pathogen. Azithromycin has limited and inconsistent coverage of Pasteurella and poor anaerobic activity. Thus, Clavamox is the most appropriate initial antibiotic.